Human Cancer Biology Rab25 Regulates Invasion and Metastasis in Head and Neck Cancer
نویسندگان
چکیده
Purpose:Head andneck squamous cell carcinoma (HNSCC) is one of the 10most common cancers with a 50% five-year survival rate, which has remained unchanged for the past three decades. One of the major reasons for the aggressiveness of this cancer is that HNSCCs readilymetastasize to cervical lymph nodes that are abundant in the head and neck region. Hence, discovering new molecules controlling the metastatic process as well as understanding their regulation at themolecular level are essential for effective therapeutic
منابع مشابه
Rab25 in head and neck cancer metastasis 1 Rab25 regulates invasion and metastasis in head and neck cancer
Panomwat Amornphimoltham, Kamil Rechache, Jamie Thompson, Andrius Masedunskas, Kantima Leelahavanichkul, Vyomesh Patel, Alfredo Molinolo, J. Silvio Gutkind, and Roberto Weigert* Intracellular Membrane Trafficking Unit and 2 Molecular Carcinogenesis Unit Oral and Pharyngeal Cancer Branch National Institute of Dental and Craniofacial Research, National Institutes of Health 30 Convent Dr. Building...
متن کاملRab25 regulates invasion and metastasis in head and neck cancer.
PURPOSE Head and neck squamous cell carcinoma (HNSCC) is one of the 10 most common cancers with a 50% five-year survival rate, which has remained unchanged for the past three decades. One of the major reasons for the aggressiveness of this cancer is that HNSCCs readily metastasize to cervical lymph nodes that are abundant in the head and neck region. Hence, discovering new molecules controlling...
متن کاملAnti-invasion Effects of Cannabinoids Agonist and Antagonist on Human Breast Cancer Stem Cells
Studies show that cancer cell invasion or metastasis is the primary cause of death inmalignancies including breast cancer. The existence of cancer stem cells (CSCs) in breast cancermay account for tumor initiation, progression, and metastasis. Recent studies have reporteddifferent effects of cannabinoids on cancer cells via CB1 and CB2 cannabinoid receptors. In thepresent study, the effects of ...
متن کاملAnti-invasion Effects of Cannabinoids Agonist and Antagonist on Human Breast Cancer Stem Cells
Studies show that cancer cell invasion or metastasis is the primary cause of death inmalignancies including breast cancer. The existence of cancer stem cells (CSCs) in breast cancermay account for tumor initiation, progression, and metastasis. Recent studies have reporteddifferent effects of cannabinoids on cancer cells via CB1 and CB2 cannabinoid receptors. In thepresent study, the effects of ...
متن کاملThe Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines
It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...
متن کامل